Leucovorin (Folinic Acid) Treatment for Autism

At Dr. Joe Concierge Pediatrics, we believe in looking beyond labels to uncover underlying medical factors that can impact a child’s development. One promising area of research involves folate metabolism and brain health in children with autism spectrum disorder (ASD).

What is Leucovorin?

Leucovorin (also called folinic acid) is an active form of folate (vitamin B9). Unlike regular folic acid, it can bypass certain blocks in the body’s ability to use folate. Some children with autism have folate receptor autoantibodies (FRAAs) that prevent folate from reaching the brain — a condition sometimes called cerebral folate deficiency.

Research has shown that treatment with leucovorin may improve:

• Language and communication

• Social interaction and engagement

• Attention and focus

• Behavior and mood

Who May Benefit?

Children who test positive for FRAA/FRAT are most likely to benefit, but improvements have also been reported in some children without antibodies. Testing is available in-office to help guide treatment decisions.

How the Program Works

Our Leucovorin Treatment Program is offered in-office as part of our biomedical services for autism. It includes:

• Initial evaluation and baseline labs

• FRAA/FRAT testing (when appropriate)

• Customized dosing and prescription of leucovorin

• Regular follow-ups to monitor progress and side effects

• Ongoing access to Dr. Joe for questions and support

Treatment is closely supervised and fully integrated into your child’s overall care plan.

Safety & Monitoring

Leucovorin is generally well tolerated, but may cause side effects such as irritability, hyperactivity, sleep changes, or gastrointestinal upset. Rarely, seizures have been reported. For this reason, all treatment is physician-guided with careful monitoring and follow-up.

​​​​​​​Why Choose Dr. Joe Concierge Pediatrics?

Families in St. Louis trust Dr. Joe not only as a pediatrician but also as a parent who understands the importance of personalized care. With nearly two decades of pediatric experience, Dr. Joe offers a whole-child, concierge approach — blending traditional medicine with evidence-based biomedical supports.

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